Warfarin Pharmacodynamics After Conversion to Sinus Rhythm
Warfarin Pharmacodynamics After Conversion to Sinus Rhythm
Warfarin dosages required to maintain a goal INR of 2.0–3.0 were relatively stable in the four weeks before and after procedures to convert atrial fibrillation or flutter to sinus rhythm. Changes in the weekly warfarin dose requirement of ≥10% after the procedures were implemented in a small proportion of patients. The mean weekly warfarin dose was significantly lower in the three months after than in the three months before the procedure.
Conclusion
Warfarin dosages required to maintain a goal INR of 2.0–3.0 were relatively stable in the four weeks before and after procedures to convert atrial fibrillation or flutter to sinus rhythm. Changes in the weekly warfarin dose requirement of ≥10% after the procedures were implemented in a small proportion of patients. The mean weekly warfarin dose was significantly lower in the three months after than in the three months before the procedure.