Pentaerithrityl Tetranitrate in Chronic Stable Angina

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´╗┐Pentaerithrityl Tetranitrate in Chronic Stable Angina


Nitrates are still commonly used as add-on therapy in patients who remain symptomatic despite administration of beta-blockers or calcium-channel antagonists. Although they are generally considered to belong to a homogenous class without relevant differences among molecules, important differences have been recently shown between PETN, on the one side, and GTN and isosorbide compounds, on the other. The current trial formally addressed the anti-anginal effect of PETN. Although having no significant effect on exercise capacity in unselected CAD patients, PETN may provide an additional benefit as add-on therapy in selected symptomatic patients.

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